| Affton High School | McCluer High School |
| Bishop DuBourg High School | McCluer North High School |
| Brentwood High School | McKinley Classical Leadership Academy |
| Cardinal Ritter College Prep | Mehlville High School |
| Central Visual and Performing Arts High School | Metro Academic and Classical High School |
| Chaminade College Preparatory School | Miriam High School |
| Christian Brothers College High School | Nerinx Hall |
| Clayton High School | Normandy High School |
| Collegiate School of Medicine and Bioscience | Northwest High School |
| Columbia Area Career Center | Notre Dame High School |
| Cor Jesu Academy | Oakville High School |
| Crystal City High School | Orchard Farm High School |
| De Smet Jesuit High School | Pacific High School |
| Duchesne High School | Parkway Central High School |
| Epstein Hebrew Academy | Parkway North High School |
| Esther Miller Bias Yaakov High School | Parkway South High School |
| Eureka High School | Parkway West High School |
| Fern Ridge High School | Pattonville High School |
| Festus High School | Perryville High School |
| Fort Zumwalt East High School | Principia Upper School |
| Fort Zumwalt North High School | Rockwood Summit High School |
| Fort Zumwalt South High School | Seckman High School |
| Fort Zumwalt West High School | Soldan International Studies High School |
| Fox Senior High School | St. Charles High School |
| Francis Howell Central High School | St. Charles West High School |
| Francis Howell High School | St. Dominic High School |
| Francis Howell North High School | STEAM Academy at McCluer South-Berkeley |
| Gateway Science Academy of St. Louis | St. John Vianney High School |
| Gateway STEM High School | St. Joseph's Academy |
| Grand Center Arts Academy | St. Louis University High School |
| Hancock Place High School | St. Mary's South Side Catholic High School |
| Hazelwood Central High School | St. Pius X High School |
| Hazelwood East High School | Sumner High School |
| Hazelwood West High School | Timberland High School |
| Heritage Classical Christian Academy | Troy Buchanan High School |
| Hillsboro High School | University City High School |
| Holt High School | Ursuline Academy |
| Incarnate Word Academy | Valle Catholic High School |
| Kirkwood High School | Valley Park High School |
| Lafayette High School | Veritas Christian Academy |
| Liberty High School | Warrenton High School |
| Lindbergh High School | Webster Groves High School |
| Lutheran North High School | The Whitfield School |
| Maplewood Richmond Heights High School | Windsor High School |
| Marquette High School | |