The Medicinal Chemistry Group at UMSL can provide a wide array of services to meet your research needs.

  • Synthesis of research or tool compounds
  • Strategy, design and synthesis of new molecules
  • Lead optimization employing sophisticated SAR (structure activity relationships) tools and structure based design principles
  • Targeted library design and synthesis (up to 250 membered libraries)
  • Medicinal chemistry strategies to achieve superior ADMET properties
  • Scale-up synthesis of lead compounds/advanced intermediates (multi-gram quantities)
  • Custom synthesis
  • Consultation for process development/route optimization
  • Patent analysis

The Medicinal Chemistry Group possesses a full complement of synthesis, purification and analytical tools to ensure high quality results.

  • Chromatography (normal and reverse phase)
  • LC-MS capabilities
  • High-pressure reactions/hydrogenations
  • Parallel Chemistry
  • Low temperature reactions
  • Chiral Synthesis (auxiliaries or catalysts)
  • Metal catalyzed cross-couplings
  • Reductive aminations
  • Peptide couplings

Offerings available through the Center for Nanoscience at UMSL

Microscopy Image and Spectroscopy Technology Laboratory

X-ray Diffraction Laboratory

Molecular Modeling and Simulation

High Field NMR Facility

Mass Spectrometry Facility