Capabilities
The Medicinal Chemistry Group at UMSL can provide a wide array of services to meet your research needs.
- Synthesis of research or tool compounds
- Strategy, design and synthesis of new molecules
- Lead optimization employing sophisticated SAR (structure activity relationships) tools and structure based design principles
- Targeted library design and synthesis (up to 250 membered libraries)
- Medicinal chemistry strategies to achieve superior ADMET properties
- Scale-up synthesis of lead compounds/advanced intermediates (multi-gram quantities)
- Custom synthesis
- Consultation for process development/route optimization
- Patent analysis
The Medicinal Chemistry Group possesses a full complement of synthesis, purification and analytical tools to ensure high quality results.
- Chromatography (normal and reverse phase)
- LC-MS capabilities
- High-pressure reactions/hydrogenations
- Parallel Chemistry
- Low temperature reactions
- Chiral Synthesis (auxiliaries or catalysts)
- Metal catalyzed cross-couplings
- Reductive aminations
- Peptide couplings
Offerings available through the Center for Nanoscience at UMSL
Microscopy Image and Spectroscopy Technology Laboratory