Keith J. Stine, Chair
Undergraduate Program Advising
Undergraduate Scholarships and Awards
Research for Undergraduates
Graduate Program Overview
Application to Graduate Program
Graduate Program Contact Information
Faculty Contact Information
Graduate Student Seminars
Robert W. Murray Lecture
Distinguished Alumni Lecture
Visiting Speaker Seminars
Chung F. Wong, B.Sc. (Hons.), Chinese University of Hong Kong, Ph.D. the University of Chicago, did postdoctoral work at the University of Houston. He held academic and industrial positions at the University of Houston, Mount Sinai School of Medicine, SUGEN, Inc., University of California-San Diego, and the Howard Hughes Medical Institute before joining the faculty of UMSL in 2004.
Our research involves the development and applications of computational methods to study biomolecular structure, dynamics, and function and to aid the design of bioactive compounds. For details please go to the link above to the laboratory homepage.
″Using machine learning to improve ensemble docking for drug discovery″, T. Chandak, J. P. Mayginnes, H. Mayes and C. F. Wong, Prot. Struct. Func. & Bioinf. 2020, Ahead of Print.
″Improving ensemble docking for drug discovery by machine learning,″ C. F. Wong, J. Theoret. Comp. Chem. 2019, 18, 1920001.
"Steered molecular dynamics simulations for uncovering the molecular mechanisms of drug dissociation and for drug screening: A test on the focal adhesion kinase," C. F. Wong, J. Computational Chem. 2018, 39, 1307.
″Program for Simulating Gel Electrophoresis of Enzyme-Digested Proteins, ″ H. Mayes and C. F. Wong, J Chem. Ed. 2018, 95, 2064.
″Variable van der Waals Radii Derived From a Hybrid Gaussian Charge Distribution Model for Continuum-Solvent Electrostatic Calculations,″ R. Ye, X. Nie, C. F. Wong, X. Gong, Y. A. Wang, T. Heine and B. Zhou, Baojing, Z. Phys. Chem. 2016, 230, 681
″Incorporating binding kinetics in drug design, ″ C. F. Wong, In: Silico Drug Discovery and Design, C. N. Cavasotto, Ed, 2016, 483-503
″Exploring host-guest complexation mechanisms by a molecular dynamics/quantum mechanics/continuum solvent model approach,″ R. Ye, X. Nie, Y. Zhou, C. F. Wong, X. Gong, W. Jiang, W. Tang, Y. A. Wang,T. Heine and B. Zhou, Chem. Phys. Lett. 2016, 648, 170
″Inexpensive Method for Selecting Receptor Structures for Virtual Screening,″ Z. Huang and C. F. Wong, J. Chem. Inf. & Modeling 2016, 56, 21.
″Conformational transition paths harbor structures useful for aiding drug discovery and understanding enzymatic mechanisms in protein kinases,″ C. F. Wong, Protein Science 2016, 25, 192.
″Brownian Dynamics Simulation of Peptides with the University of Houston Brownian Dynamics (UHBD) Program,″ T. Shen and C. F. Wong, Methods in Molecular Biology, 2015, 1268, 75.
″Flexible receptor docking for drug discovery,″ C. F. Wong, Expert Opinion on Drug Discovery, 2015, In press.
"A New Class of Salicylic Acid Derivatives for Inhibiting YopH of Yersinia pestis", M. P. Paudyal, L. Wu, Z.-Y. Zhang, C. D. Spilling and C. F. Wong, Bioorg. Med. Chem. 2014, 22, 6781.
"Molecular simulation of drug-binding kinetics″, C. F. Wong, Molecular Simulation, 2014, 40, 889.
"Drug design for Protein Kinases and Phosphatases: Flexible-Receptor Docking, Binding Affinity and Specificity, and Drug-Binding Kinetics" C. F. Wong and S. Bairy, Curr. Pharm. Design 2013, 19, 4739.
"SRmapper: a fast and sensitive genome-hashing alignment tool' P. M. Gontarz, J. Berger and C. F. Wong, Bioinformatics 2013, 29, 316.