Chemistry and Biochemistry

Nigam P. Rath


Nigam P. Rath

Dr. Rath received B.Sc. (Hons.) and M.Sc. degrees from Berhampur University in India, and a Ph.D. from Oklahoma State University. He was a Postdoctoral Fellow and Assistant Faculty Fellow at the University of Notre Dame prior to joining the UM-St. Louis faculty as Research Assistant Professor in 1989. He was promoted to Research Associate Professor in 1996 and Research Professor in 2004.

Office: N304
Phone: (314) 516-5333
Fax: (314) 516-5342

Research Interests

Dr. Rath's research interests involve the use of single crystal X-ray diffraction techniques for three dimensional solid state-molecular and crystal structure determination of novel organic and organometallic compounds. Currently, Dr. Rath is the Director of the X-ray Diffraction Laboratory of the Department of Chemistry and Biochemistry and the Center for Nanoscience. Current research interests include study of weak interactions in the solid state, polymorphism, structure solution and refinement of twin structures and development of techniques and instrumentation for accurate data collection for small molecules.

Selected Publications

″Synthesis of a smoothened cholesterol: 18,19-Di-nor-cholesterol″, L. Mydock-Mcgrane, N. P. Rath and D. F. Covey, J. Org. Chem. 2014, 79, 5636.

″New bis(imino)pyridine complexes of iron(II) and iron(III), and their catalytic-activity in the Mukaiyama aldol reaction″, P. Shejwalkar, N. P. Rath and E. B. Bauer, Synthesis, 2014, 46, 57

"Ruthenium complexes of the general formula [RuCl2(PHOX) 2] and their catalytic activity in the Mukaiyama aldol reaction," N. Curvey, A. K.  Widaman, N. P. Rath and E. B. Bauer, Tetrahedron Lett. 2014, 55, 3033.

″Synthesis and Characterization of Pt(II) and Pd(II) PTA and DAPTAcomplexes″, J. Braddock-Wilking, A.Sitaram and N. P. Rath, Polyhedron 2014, 79, 16. 

"A thiocynato-bridged copper(i) cubane complex and its application in palladium-catalyzed Sonogashira coupling of aryl halides," M. Trivedi, G. Singh, A. Kumar Abhinav and N. P. Rath, Dalton Trans. 2013 42, 12849 

"Oxidative reactivity of (N2S2)PdRX complexes (R = Me, Cl; X = Me, Cl, Br): involvement of palladium(II) and palladium(IV) intermediates," J. Luo, N. P. Rath, and L. M. Mirica, Organometallics 2013, 32, 3343

 "Late First Row Transition Metal Complexes of a Tetradentate Pyridinophane Ligand: Electronic Properties and Reactivity Implications," J. R. Khusnutdinova, J. Luo, N. P. Rath and L. M. Mirica, Inorg. Chem. 2013, 52, 3920

 "Role of Substitution at Terminal Nitrogen of 2-Oxo-1,2-dihydroquinoline-3-Carbaldehyde Thiosemicarbazones and the Coordination Behavior and Structure and Biological Properties of Their Palladium(II) Complexes," E. Ramachandran, D. R. Senthil, N. P. Rath and K. Natarajan, Inorg. Chem. 2013, 52, 1504.

"Iron(III) a-Aminopyridine Complexes and their Catalytic Activity in Oxidation Reactions: A Comparative Study of Activity and Ligand Decomposition," M.  Lenze, E. T. Martin, N. P. Rath and E. B. Bauer, ChemPlusChem 2013, 78, 101.

"Structure-property trends in cyano-bridged tetranuclear FeIII/NiII single-molecule magnets," Y-Z. Zhang, U. P. Malik, R. Clerac, N. P. Rath and S. M. Holmes, Polyhedron201352, 115.

"Synthesis, Structures, and Magnetic Properties of a Novel mer-[(bbp)FeIII(CN)3]2- Building Block (bbp:bis(2-benzimidazolyl)pyridine dianion) and Its Related Heterobimetallic Fe(III)-Ni(II) Complexes," A. Panja, P. Gi\uionneau, I-R Jeon, S. M. Holmes, R. Clerac and C. Mathoniere, Inorg. Chem201251, 12350

"Cycloaddition reactivity studies of first-row transition metal-azide complexes and alkynes: an inorganic click reaction for metalloenzyme inhibitor synthesis," E.  Evangelio, N. P. Rath and L. M. Mirica, Dalton Trans. 201241, 8010.

 "Formation of Palladium(IV) complex [(Me3tacn)PdIVMe3]+ through Aerobic Oxidation of (Me3tacn)PdIIMe2 (Me3tacn = N,N',N'' –Trimethyl-1,4,7-triazacyclononane)," J. R. Khusnutdinova, F. Qu, Y.  Zhang and  N. P.  Rath, and L. M. Mirica,  Organometallics201231, 4627

 "The synthesis and receptor binding affinities of DDD-016, a novel, potential, atypical antipsychotic," A. Bandyopadhyaya, R. Achintya; R. Desikan N. P. Rath, A. Herrold, R. Rajagopalan, T. C.  Napier, C. E. Tedford and P. Rajagopalan,  MedChemComm20123, 580

 "Rapid acyl migration between pyrogallyl 1,2- and 1,3-dipivaloates," Y. Shan, J. Liu, N. P. Rath and G. W. Gokel, Nat. Prod. Commun.  2012, 7, 333.

UMSL X-ray Diffraction Laboratory