Cynthia M. Dupureur

Professor Dupureur received her B.S. degree from Southwest Missouri State University, and her Ph.D. from Ohio State University. She joined the UM-St. Louis Chemistry faculty in 2001. She held a faculty position at Texas A&M following postdoctoral fellowship at the California Institute of Technology.  She is now Professor of Chemistry and Biochemistry and was appointed Department Chair, effective August 1, 2016.
Office: N307
Tel: (314)516-4392
Fax: (314)516-5342

Research Interests

My group is interested in structure-function relationships for biomolecules. This involves developing an understanding of how structural elements give rise to specific functions like enzymatic catalysis and molecular recognition. For a number of years, my group has explored restriction enzymes and how they combine DNA sequence recognition with metal ion-mediated hydrolytic chemistry. More recently we have turned our hands to collaborative projects with synthetic chemists. One involves the study of esterases, with a particular interest in the diabetes drug target hormone sensitive lipase. A newer project involves biophysical studies of DNA interactions with polyamides, which show promise as HPV drugs. Over the history of the group, our studies have involved a wide array of techniques including basic molecular biology, enzyme kinetics, computational chemistry, calorimetry, and fluorescence and NMR spectroscopies. This research style provides excellent opportunities to master a number of biophysical and mechanistic approaches.


Recent Publications

″Spectroscopic investigation and direct comparison of the reactivities of iron pyridyl oxidation catalysts,″ Y. Song, H. G. Mayes, M. J. Queensen, E. B. Bauer and C. M. Dupureur, Spectrochimica Acta, 2017, 174, 130.

″Improved Antiviral Activity of a Polyamide Against High-Risk Human Papillomavirus Via N-Terminal Guanidinium Substitution,″ C. H. Castaneda, J. M. Scuderi, T. G. Edwards, G. D. Harris, C. M. Dupureur, K. J. Koeller, C. Fisher and J. K. Bashkin, MedChemComm. 2016, 7, 2076.

″Interactions of two large antiviral polyamides with the long control region of HPV16,″ E. Vasilieva, J. Niedershulte, Y. Song, J. K. Bashkin and C. M. Dupureur, Biochemie, 2016, 127, 103.

″Synthesis and comparison of the biological activity of monocyclic phosphonate, difluorophosphonate and phosphate analogs of the natural AChE inhibitor cyclophostin,″ B. P. Martin, E. Vasilieva, C. M. Dupureur and C. D. Spilling, Bioorg. & Med. Chem. 2015, 23, 7529.

″Rat hormone sensitive lipase inhibition by cyclopostins and their analogs″, E. Vasilieva, S. Dutta, R. K. Malla, B. P. Martin, C. D. Spilling and C. M. Dupureur, Bioorganic & Med. Chem. 2015, 23, 944. 

″Structural Insights into the Interaction between a Potent Ant-inflammatory Protein, Viral CC Chemokine Inhibitor (vCC), and the Human CC Chemokine Eotaxin″, N-W. Kuo, Y-G. Gao, M. Schill, N. Isern, C. M. Dupureur and P. J. Li Wang, J. Biol. Chem. 2014, 289, 6592.

"Binding studies of a large antiviral polyamide to a natural HPV sequence”’ G. He, E. Vasilieva, G. D. Harris, K. J. Koeller, J. K. Bashkin and C. M. Dupureur, Biochimie 2014, 102, 83.

"Mapping small DNA ligand hydroxyl radical footprinting and affinity cleavage products for capillary electrophoreses," G. He, E. Vasilieva; J. K. Bashkin, C. M. Dupureur, Anal. Biochem. 2013, 439, 99

"Promoter scanning of the human COX-2 gene with 8-ring polyamides: Unexpected weakening of polyamide–DNA binding and selectivity by replacing an internal N-Me-pyrrole with β-alanine," J. K. Bashkin, K. Aston, J. P. Ramos, K. J. Koeller, R. Nanjunda, G. He, C. M. Dupureur and W. D. Wilson, Biochimie, 2013, 95, 271.

"Fluorescence assay of polyamide-DNA interactions," C. M. Dupureur, J. K. Bashkin, K. Aston, K. J. Koeller, K. R. Gaston and G. He, Anal. Biochem. 2012, 423, 178.

"ORAC Values and Anthocyanin content of Brazilian and Floridian Acia (Euterpe oleraceae Mart," C. M.Dupureur, A. U. O. Sabaa-Srur, K. Tran. P. S. Shejwalker and R. E. Smith, Nat. Prod. J. 2012, 2, 99

"Fluorescence assay of polyamide-DNA interactions,"  C. M. Dupureur, J. K. Bashkin, K. Aston, K. J. Koeller, K. R. Gaston and G. He, Anal. Biochem. 2012, 423, 178. 

"DNA targeting and cleavage by an engineered metalloprotein dimer," S. W. Wong-Deyrup, C. Prasannan, C. M. Dupureur and S. J. Franklin, J. Biol. Inorg. Chem. 2012, 17, 387. 

"Metal ion and DNA binding by single-chain PvuII endonuclease: lessons from the linker," G. A. Papadakos and C. M. Dupureur, J. Biol. Inorg. Chem. 2011, 16, 1269.

"The First Total Synthesis of ()-Cyclophostin and ()-Cyclipostin P: Inhibitors of the Serine Hydrolases Acetyl Cholinesterase and Hormone Sensitive Lipase", R. K. Malla, S Bandyopadhyay, C. D. Spilling, S. Dutta and C. M. Dupureur, Organic Lett. 2011, 13, 3094.