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Professor Demchenko received his M. Sc. in Chemical Engineering from D. I. Mendeleyev University of Chemical Technology of Russia, Moscow (1988) and received his Ph. D. in Organic Chemistry from N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow (1993). He was a BBSRC post-doctoral research fellow at School of Chemistry, University of Birmingham, United Kingdom and a research assistant at the Complex Carbohydrate Research Center, University of Georgia, Athens before joining the UM-St. Louis faculty in 2001. Professor Demchenko was appointed Curators' Professor of Chemistry and Biochemistry in 2014.

demchenkoa@umsl.edu Fax: (314) 516-5342
Office: B434
Tel: (314) 516-7995 Glycoworld (Alexei Demchenko Laboratory Homepage)

Research Interests

Figure 2

Selected Publications

″Hydrogen bond mediated aglycone delivery: Synthesis of linear and branched α-glucans″, J. P. Yasomanee and A. V. Demchenko, Angew Chem. Intl Ed. 2014 (n press).

″Glycosyl alkoxythioimidates as building blocks for glycosylation: a reactivity study″ S. C. Ranade and A. V. Demchenko, Carbohydrate Res. 2014 (in press).

"2-acylamido analogues of n-acetylglucosamine prime formation of chitin oligosaccharides by yeast chitin synthase 2,"J. Gyore, A. R. Parameswar, C. F. F. Hebbard, Y. Oh, E. Bi, A. V. Demchenko, N. P. Price and P. Orlean, J. Biol. Chem. 2014, 289, 12835

"Hydrogen-bond-mediated aglycone delivery: Focus on β-mannosylation,"  S. G. Pistorio, J. P. Yasomanee and A. V. Demchenko," Org. Lett. 2014, 16, 716

“Regenerative Glycosylation under Nucleophilic Catalysis”, S. S. Nigudkar, K. J. Stine and  A. V. Demchenko, J. Am. Chem. Soc., 2014, 126, 921.

"Square-wave voltammetry assays for glycoproteins on nanoporous gold," B. Pandey, J. K. Bhattarai, P. Pornsuriyasak, K. Fujikawa,R. Catania, A. V. Demchenko and K. J. Stine, J. Electroanal. Chem. 2014, 717/718, 47.

"A Comparative Study of Glycosyl Thioimidates as Building Blocks for Chemical Glycosylation," S. C. Ranade, S. J. Hasty and A. V. Demchenko, J. Carbohydrate Chem. 2013, 32, 360.

 "Super-Arming of Glycosyl Donors by Combined Neighboring and Conformational Effects.," M. Heuckendorff, H. D. Premathilake, P. Pornsuriyasak, A. O. Madsen, C. M. Pedersen, M. Bols and A. V. Demchenko, Org. Lett. 2013, 15 41004

 "Reactive thiogluciside-substrates for b-glucosidase," A. E. Alverson-Banks, S. J. Hasty, A. R. Parameswar, G. S. Howarth, A. V. Demchenko and L. D. Byers, Arch. Biochem. Biophys. 2013, 537, 1

"Surface-Tethered Iterative Carbohydrate Synthesis: A Spacer Study," V. N. Ganesh, K. Fujikawa, Y-H. Tan, S. S. Nigudkar, K. J. Stine and A. V. Demchenko, J. Org. Chem. 2013, 78, 6849.

“O-Benzoxazolyl imidates as versatile glycosyl donors for chemical glycosylation”, Swati S. Nigudkar, Archana R. Parameswar, Papapida Pornsuriyasak, K. J. Stine, and A.i V. Demchenko, Org. and Biomol. Chem., 2013, 11, 4068.

“Lectin-Carbohydrate Interactions on Nanoporous Gold Monoliths”, Y.-H. Tan, K. Fujikawa, P. Pornsuriyasak, A. J. Alla, A. V. Demchenko and K. J. Stine, New J. Chem., 2013, 37, 2150.

"Mechanism of Chemical Glycosylation: focus on the Node of Activation and Departure from Anomeric Leaving Groups," S. C. Ranade and A. V. Demchenko,  J. Carbohydrate Chem2013, 32, 1.

"Effect of Remote Picolinyl and Picolyl Substituents on the Stereoselectivity of Chemical Glycosylation. J. P.  Yasomanee and A. V. Demchenko, J. Am. Chem. Soc. 2012, 134, 20097.

“Electrochemical Characterization of Globotriose-Containing Self-Assembled Monolayers on Nanoporous Gold and their Binding of Soybean Agglutinin”, B. Pandey, Y. H. Tan,  A. R. Parameswar, P. Pornsuriyasak, A. V. Demchenko and K.  J. Stine, Carbohydrate Research, 2012, 373, 9.