The Neuropsychology and Applied Neuroimaging Laboratory (NAN) is largely focused on understanding the contribution of subcortical brain systems to cognitive and affective behavior. Our lab focuses on two conditions that provide opportunities to study subcortical brain systems, including subcortical ischemic vascular disease (SIVD) associated with advanced age, and human immunodeficiency virus (HIV). The neuropathology of SIVD and HIV predominately involves both white matter and subcortical gray matter structures. Our research studies typically incorporate neuropsychological tests to examine behavioral indices of brain function. These tests are weighted towards domains of function subserved by subcortical brain systems (e.g., information processing speed). The NAN research program at UMSL incorporates structural neuroimaging, diffusion tensor imaging, and functional neuroimaging to explore the neuronal integrity of brain systems. The neuroimaging aspects of our research program are conducted in collaboration with co-investigators based at Washington University School of Medicine, Brown Medical School, Harvard Medical School, and the University of Sydney.