1:00-2:00 Keynote Talk: Prof. Peter Tass. Vibrotactile Coordinated Reset Stimulation for the Therapy of Parkinson’s Disease: Theory and Clinical Results.
2:00-2:15 Virtual Poster Session
Kenneth Smith, Jamie Lea, Carlos Cruchaga and Sharlee Climer. CSF Protein Co-Expression Implicates PI3K-Akt Pathway Involvement in Alzheimer’s Disease.
Christina Garasky, Theresa Moore, Taylor Jancetic, Anne Brown, Tabish Gul, Lane Soylu, Bridget Muise, Symphony Hopkins and Bettina Casad. Threatening Virtual Classrooms: Vigilance to (Non)-Diversity Cues Affects Women’s Science Test Performance.
2:15-2:27 Justus Kromer, Ali Khaledi-Nasab and Peter Tass. Stimulation-induced Long-lasting Desynchronization of Plastic Neuronal Networks.
2:27-2:39 Adam Runyan, S. Pessin, C. Velez, B.S.C. Wade, D.B. Cooper, R. D. Vanderploeg, J.E. Kennedy, A.O. Bowles, G. Curtiss, J. Lewis, A.M. Drennon, J. Ritter, G. York, D.F. Tate and Carissa Philippi. Neural Substrates of Working Memory Regions in mTBI & PTSD: An fMRI study.
2:39-2:51 Navneet Kaur and Badri Adhikari. Real-time Surya-namaskar Yoga Pose Identification Using Deep Learning.
2:51-2:54 Rachel Brant. Three-Minute Thesis Talk: Differential Gene Expression and Behavioral Diversity of an Urban Dwelling Sweat Bee, Halictus ligatus.
2:51-3:03 Ishan Pathak and Sonya Bahar. Phase Cluster States in a Two-hemisphere Neuron Model.
3:06-3:18 Shikha Grover, Thao Pham, Anna Jones, Cristina Sinobas Pereira and Michael R. Nichols. Probing Amyloid-beta Protein Structure and Dynamics with a Selective Antibody.
3:18-3:30 Kapur Dhami, Shikha Grover and Michael R. Nichols. Intermediate A-beta Species with Classical Beta-sheet Structure Enhance Proinflammatory Activity.
~ Short talks will be 10 minutes, with 2 minutes for questions. ~
Vibrotactile Coordinated Reset Stimulation for the Therapy of Parkinson’s Disease: Theory and Clinical Results
Abnormally strong synchronization of neuronal activity is a hallmark of several brain disorders, such as Parkinson’s disease (PD). In PD patients, permanent high-frequency deep brain stimulation suppresses symptoms during stimulus delivery. A qualitatively different, theory-based approach uses dedicated patterns of electrical stimuli delivered to brain tissue to cause a desynchronization-induced decoupling of oscillatory neurons, intending to move neural networks from attractors with abnormal neural synchrony to more physiological (desynchronized) attractors. Corresponding cumulative and long-lasting therapeutic and desynchronizing effects were demonstrated in animal and clinical studies.
By replacing invasively delivered electrical bursts with non-invasively administered vibratory bursts, we have developed a non-invasive approach: Vibrotactile Coordinated Reset (vCR) stimulation delivered to the fingertips was designed to treat PD patients by inducing long-lasting desynchronization. In a feasibility study, six PD patients were treated with vCR stimulation delivered for four hours per day for three months. Patients’ conditions were evaluated after medication withdrawal (‘off medication’) by means of standard clinical scores and EEG recordings before and after the 3-month vCR treatment. In accordance with vCR-related computational studies, months-long vCR therapy causes a statistically and clinically significant reduction of PD symptoms off medication together with a significant reduction of high beta (21-30 Hz) power in the sensorimotor cortex. The ultimate goal of this approach is to induce sustained symptom relief by non-invasively delivering desynchronizing stimulus patterns only regularly or occasionally.
Remembering Frank Moss (1934-2011)
The Center for Neurodynamics, the UMSL community, and many scientists throughout the world continue to mourn the loss of Frank Moss. January 4, 2021 marked the tenth anniversary of his death, and his friends and colleagues still find it difficult to wrap their minds around the idea that he is gone.
This past year has seen several international workshops held in Frank’s honor. A special Focus Issue of the journal Chaos appeared in December 2011, dedicated to Frank, and collecting a wide range of papers in the field of complex stochastic dynamics in biology, which he helped to found.