George W. Gokel Laboratory
Hydraphile Cation Channels
Hydraphile channels use crown ethers as amphiphilic head groups and as entry portals to create a pore within a bilayer membrane. Cations transport through the channels, which exhibit classic open-close behavior typical of protein channels.
A family of synthetic anion transporters (SATs) has been prepared. These extensively substituted peptide derivatives mediate the transport of chloride and other anions through phospholipid bilayers.
Synthetic receptors have been used to define the interactions between alkali metal cations and benzene, phenol, and indole, the common amino acid arenes.