Current Research Interests

Drug Discovery

1). Develop computational methods to aid drug discovery
2). Design drugs to target protein kinases and phosphatases, usually in collaboration with experimentalists


1). Develop new tools for aligning DNA fragments from next-generation sequencing experiments to reference genomes to help construct whole-genome sequences
2). Explore efficient means to use next-generation sequencing to detect pathogens from clinical and environmental samples


Our research has benefited greatly from the contributions from many talented students, productive postdoctoral fellows, and knowledgeable senior collaborators, and the financial supports from the National Institute of General Medical Sciences, the National Cancer Institute, the National Institute of Allergy and Infectious Diseases, the Petroleum Research Fund, the John von Neumann Center, the Pittsburgh Supercomputing Center, the Pacific Northwest National Laboratory, the National Science Foundation Advanced Computing Resources, Extreme Science and Engineering Discovery Environment, the Mount Sinai School of Medicine, New York University, the University of Missouri Research Board, the University of Missouri-St. Louis, and the University of Missouri Bioinformatics Consortium.