| 1) On Highway I-70, traveling east or west: | Exit Hwy I-70 at the Hanley Road Exit. Turn south and continue approximately 1/2 mile to the intersection of Natural Bridge and Hanley Road. Turn left onto Natural Bridge and continue to the first stop-light. The UMSL Newman House is located on the right side of the street at the corner. |
| 2) On Highway I-170, traveling north or south: | Exit Highway I-170 at the Natural Bridge Exit and turn right (east). Continue on Natural Bridge Road through the Hanley Road intersection. The UMSL Newman House is located on the right side of the street at the corner of the first stop-light after Hanley Road. |
| 3) On Highway I-270 traveling west or east: | Exit Highway I-270 at Highway I-170 South and follow (2) above |
| 4) On Highway I-270 traveling north or south: | Exit Highway I-270 at Highway I-70 East and follow (1) above |
| 5) On Highway I-64-40 traveling east: | Exit Highway 64-40 at Highway I-270 North; continue north to Highway I-70 East and follow (1) above. |
| 6) On Highway I-64-40, traveling west: | Exit Highway I-64-40 at Highway I-170 North and follow (2) above. |
| 7) Traveling from Illinois on Highway I-64 west: | Cross the Poplar Street Bridge and continue west on Highway I-70 and follow (1) above. |