Study Question Sets for Exam 2 Study Question Set 8 Nuclear Structure,
ER Structure & SER Function
Explain in general terms how chromatin compacts DNA in the interphase nucleus of a eukaryotic cell.
There is a correlation between the number of nuclear pores found in a cell's
nucleus and the extent of protein synthesis in that cell. Why would this be
the case?
Describe the general organization of the nuclear pore complex.
Describe the relationship between the nuclear envelope and ER.
Describe the nuclear lamina in general terms.
Describe, in general terms, the connections among the nuclear lamina, chromatin,
and the nuclear envelope.
Describe briefly the structural features of the endoplasmic reticulum, noting
any morphological differences one would expect to see between SER and RER.
Explain why the tubular nature of the SER is optimal for SER function, whereas
it would not be optimal for RER function.
Indicate the general roles of SER in synthesis of membrane phospholipids.
What is the source of the name "Cytochrome P450"?
What is a "microsome"?
Adrenal cortex has hypertrophied (= highly amplified) SER. Why?
What is the role of monooxygenase reactions in "detoxification"?
Why is glycogen closely associated with SER in hepatocyes?.
Why do you think synthesis of bile acids in hepatocytes involves SER enzymes?.
Identify:
histones
nucleosomes
"beads on a string"
perinuclear space
lamins
perinuclear cisterna of RER
G6Pase, and its role in glycogen conversion to glucose
