Wordlists for Exam 2
Lectures 18, 19 & 20 Golgi Complex 2

Endocytosis

endosome system leads to lysosomes
receptor-mediated endocytosis
transferrin

ferrotransferrin - w/ Fe
apotransferrin - w/o Fe
coated pit/coated vesicle
clathrin
clathrin-coated vesicles
endocytosis recognition domain = 4 amino acid sequence
triskelion
clathrin cage
dynamin GTPase


LDL (Low Density Lipoprotein)
familial hypercholesterolemia
Brown & Goldstein, Nobel Prize 1985
early endosome
late endosome
multivesicular body

Mannose-6-phosphate (M6P)
adaptins (adaptor proteins)

Plasma membrane adaptin: AP-2
Golgi adaptins: AP-1, AP-3

Vesicle Traffic

regulated secretory pathway
constitutive secretory pathway = "default pathway"
transcytosis
transepithelial transport

e.g., uptake of maternal antibodies across infant intestinal mucosa
"COP" = Coat Protein

COP-I vesicles

retrograde vesicle movement from Golgi to ER
from early endosome toward late endosome
default secretion from TGN
COP-II vesicles - anterograde movement from ER to Pre-Golgi compartment
sec23/24 complex
sec13/31 complex
sec13/31 cage

Sar-1

VTC - vesicular tubular cluster

KKXX (double lysine)

ER Resident Proteins: Selective Retrieval uses "retention signal"
Animal "ER retention signal":
"K D E L" = Lys - Asp - Glu - Leu - COO^— = + - - (non-polar) -

Yeast "ER retention signal":  

"K D E L" = Lys - Asp - Glu - Leu - COO^— = + - - (non-polar) -

KKxx = ("double lysine motif") - ER membrane protein "retention" signal

Differentiation of Golgi Compartments

Vesicular Transport Model
Cisterna Maturation Model
Rab GTPase family
v-SNARES, t-SNARES
SNAP-25 (a t-SNARE)

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