Study Questions for Exam 1

Study Question Set 4
Proteins 2 - Three Dimensional Structure of Proteins
Revised 1/30/2004

Lehninger

Chapter 6

Problem

6 b & c

       

Osgood

Chapter 6

Topics

21, 22, 25, 28, 32, 34, 35

   

Facts

3, 9, 10, 11, 13

   

Applying

2, 3

 

Chapter 7

Topics

3, 6, 8 - 10

   

Facts

1, 2

"Topics" = "Topics for Discussion"
"Facts"     = "Do you know the facts?"
"Applying" = "Applying What You Know"


Additional Questions

  1. Do the "Biochemistry on the Internet" question from Chapter 7 of Osgood and Ocorr.
  2. Why would isoleucine be less likely to occur in a beta turn than in a beta strand?
  3. Why would aspartate be more likely to occur in a beta turn than valine? What other amino acids would occur more often in a beta turn than valine?
  4. What will determine whether regions of alpha-helical structure lie at the surface or in the interior of a water-soluble globular protein?
  5. Indicate the role of cysteine in stabilizing the tertiary structure of secretory proteins.
  6. When a globular protein folds into its native conformation, there is an increase in order of the protein (i.e., a decrease in its entropy). Explain the types of energetic factors that overcome this unfavorable entropic effect to make protein folding possble. [Consider, for different proteins, the relative contributions of favorable enthalpic (delta H) effects resulting from internal interactions (such as charge-charge interactions, internal H-bonding, and van der Waals interactions) and favorable entropic effects arising from the shielding of hydrophobic side chains from water.]
  7. Try the following internet links for studying protein structure. These links require the "Chime" browser plug-in.   (See information about downloading Chime at home.)


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Last updated 1/30/2004
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