UMSL's Mark Twain Building serves as the home facility to the UMSL men's and women's basketball teams and the UMSL volleyball team.

In the fall of 2006, the Mark Twain Building had a new wood floor installed and the University named the floor Chuck Smith Court, in honor of UMSL's first head basketball coach and Athletic Director.

The Mark Twain Building was built in the fall of 1971 to serve as the host facility for UMSL's intercollegiate athletics and recreation and intramural activities. The gym has seating to accomodate 4,736 fans, including a court-side, lower level section with chairback seats. In the summer of 2003, the University installed a new, four-sided scoreboard above the court.

After being built in 1971, the Mark Twain Building underwent a facelift in 1986 with the installation of new bleachers, including the chairback seats on the lower level. Other upgrades included a new sound system and lighting in the gym area. The gym has the ability to have three full-court basketball courts for summer camps and intramural activities as well.

Other accomodations in the Mark Twain Building include a jogging track on the lower level, a swimming pool, lockerroom facilities, weight lifting room, equipment room and a training room.