Department facilities include research and teaching laboratories, environmental chambers, greenhouses, and a large array of supporting modern research instrumentation. Graduate research can be pursued using facilities of the Missouri Botanical Garden or the Saint Louis Zoo. Several sites within an hour of campus are suitable for field studies, including state parks, wildlife conservation areas, The Shaw Nature Reserve and Washington University's Tyson Research Center. UMSL is a member of the St. Louis University Research Station Consortium that operates Lay and Reis Field Stations in Missouri and also the Organization for Tropical Studies, which operates three field stations in Costa Rica. CEIBA Biological Centre in Guyana has hosted several UMSL courses and student researchers. Student researchers work independently at research stations throughout the tropics.
The department participates in a cooperative consortium program in biology with Washington University, Saint Louis University, Southern Illinois University-Edwardsville, and the Missouri Botanical Garden.