Ben Bythell

Professor Bythell received his MChem. degree from the University of Bath, UK, in 2002 and Ph.D. from Oregon State University in 2007. He held postdoctoral fellowships at the German Cancer Research Center in Heidelberg (2008-2010) and at the National High Magnetic Field Laboratory at Florida State University (2010-2013). He joined the faculty in the fall of 2013.
Office: BH 430
(314) 516-5314
Fax: (314) 516-5342

Research Interests

Dr. Bythell works at the interface between analytical, computational and biophysical chemistry where he strives to understand the structure, reactivity and gas-phase behavior of biologically- and industrially important chemicals. Fundamentally, chemical structure determines the properties and potential functions of any given molecule. Consequently, the gas-phase structures occupied by an analyte ion have direct influence on which fragmentation pathways are populated, and thus, on the resulting mass spectrum. The ability to decipher both the elemental composition (CcHhNnOoSsPp) and structural information on unknown compounds is highly desirable. To accomplish this successfully, an understanding of the gas-phase fragmentation chemistries in play is of substantial benefit.

Ben Structure

He and his students work on how and why different analyte ions form particular conformations, and what effect this has on their gas-phase fragmentation chemistry. They utilize a wide assortment of analytical approaches based around mass spectrometry (accurate mass identification, HPLC,  isotopic labeling, tandem mass spectrometry, hydrogen/deuterium exchange, “action” IR spectroscopy), and cutting edge computational methods (molecular dynamics, density functional theory, ab initio, and RRKM calculations). In so doing, students acquire a wide variety of valuable skills, and are exposed to multiple approaches to problem-solving. 

 Selected Publications

″Proton Mobility in b2 Ion Formation and Fragmentation Reactions of Histidine Containing Peptides″, C. R. Nelson, M. T. Abutokaikah, A. G. Harrison and B. J. Bythell, Benjamin, J. Am. Soc. Mass Spect. 2016, 27, 487.

″Dissociation of gas-phase doubly-charged uranyl-acetone complexes by collisional activation and photodissociation″, M. J. Van Stipdonk, C. O’Malley, A. M. D. Plaviak, J. Pestok, P. A. Mihm, C. G. Hanley, T. A. Corcovilos, J. K. Gibson and B. J. Bythell, Int. J. Mass Spect. 2016, 396, 22.

 ″Reactions between neutral molecules and cation-radicals in the gas-phase: Can protonation occur without proton transfer?″, Y. V Vasil'ev, D. F. Barofsky, J. S.  Beckman and B. J. Bythell, Benjamin. Int. J. Mass Spect. 2015, 390, 39.

″Formation of Ions Directly from Oxazolone b2 Ions: An Energy-Resolved and Computational Study″, B. J. Bythell and A. G. Harrison,  J. Am. Soc. Mass Spectrom. 2015, 26, 774.  

“C(alpha)-Hydrogen Atom Transfer in Post-Cleavage Radical-Cation Complexes: Short and Steep versus Long Winding Road”, B. J. Bythell,  J. Phys. Chem. A, 2014, 118, 10797.

″Targeted petroleomics: Analytical investigation of macondo well oil oxidation products from pensacola beach″ B. M. Ruddy, M. Huettel, J. E. Kostka, V. V. Lobodin, B. J. Bythell, A. M. McKenna, C. Aeppli,C. M. Reddy, R. K. Nelson and A. G . Marshall,  Energy & Fuels 2014 28, 4043.

"Copper ion as a delivery platform for taxanes and taxane complexes", T. J. Manning, D. Phillips, G. Wylie, B. J. Bythell, S. Clark, R. Ogburn, K. R Ledwitch, C. Collis, S. Patterson and L. Lasseter, Bioorgan. Med. Chem. Lett. 2014, 24, 371.

"The copper (II) ion as a carrier fro the antibiotic capreomycin against Mycobacterium tuberculosis", T. J. Manning, R. Mikula, H. Lee, A. Calvin, J. Darrah, G. Wylie, D. Phillips and B. J. Bythell,  Bioorgan. Med. Chem. Lett. 2014, 24, 976.

"Ion molecule reaction H/D exchange as a probe for isomeric fractionation in chromatographically separated natural organic matter”,  A. C. Stenson, B. M. Ruddy and B. J. Bythell, Int. J. Mass Spec. 2014, 360, 45

"Insight into the Mechanism of grapheme Oxide Degradation via the Photo-Fenton Reaction”, H. Bai, W. Jiang, G. P. Kotchey, W. A. Saidi, B. J. Bythell, J. M. Jarvis, A. G. Marshall, R. A. S. Robinson and A. Star, J. Phys. Chem. C 2014, 118, 10519.

"Unequivocal determination of site-specific protein disulfide bond reduction potentials by top-down FTICR-MS Characterization of the N- and C-terminal redox-active sites in human thioredoxin", J. Scotcher, B. J. Bythell and A. G. Marshall, Anal. Chem. 2013, 85, 9164.

"Structural and some medicinal characteristics of the copper(II)-hydroxychloroquine complex", T. J. Manning, Thomas T. Leggett, D. Jenkins, I. Furtado, D. Phillips, G. Wylie, B. J. Bythell and F. Zhang, Bioorg. & Med. Chem. Lett. 2013, 23, 4453. 

"Unequivocal Determination of Site-Specific Protein Disulphide Bond Reduction Potentials by Top Down FTICR MS Characterization of the N and C Terminal Redox-Active Sites in Human Thioredoxin-1", J. Scotcher, B. J. Bythell and A. G. Marshall, Anal. Chem. 2013, 85, 9164.

“Heavy Petroleum Composition. 5. Compositional and Structural Continuum of Petroleum Revealed,” D. C. Podgorski, Y. E. Corilo, L. Nyadong, V. V. Lobodin, B. J. Bythell, W. K.  Robbins, A. M. McKenna, A. G. Marshall, and R. P. Rodgers, Energy Fuels, 2013, 27, 1268. 

“To Jump, or Not to Jump? Cα Hydrogen Atom Transfer in Post-Cleavage Radical-Cation Complexes,” B. J. Bythell,  J. Phys. Chem. A., 2013, 117, 1189.