Cynthia M. Dupureur, Department Chair
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Chemistry & Biochemistry: Summer 2017
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Robert W. Murray Lecture
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Professor McDowell received her B.A. degree from the University of Minnesota, and her Ph.D. from Washington University in St. Louis. She joined the UMSL Chemistry faculty in 2016 as Assistant Teaching Professor. Following receipt of her PhD degree she held a postdoctoral fellowship at Washington University, and held faculty appointments in Chemistry and Medicine more recently there. She has also taught at Saint Louis, Lindenwood and Maryville Universities in St. Louis.
Professor McDowell has published extensively in the area of electron transfer in biological systems as well as Rotational Echo Double Resonance NMR Spectroscopy (REDOR) including applications to biological chemistry. Her most recent work was in the area of glycosaminoglycans.Selected Recent Publications
″Glycosaminoglycans in human and bovine serum: detection of twenty-four heparan sulfate and chondroitin sulfate motifs including a novel sialic acidmodified chondroitin sulfate linkage hexasaccharide,″ H. Lu, L. M. McDowell, D. R. Studelska and L. Zhang, Glycobio. Insights, 2010, 2, 13.
″High affinity glycosaminoglycan and autoantigen interaction explains joint specificity in a mouse model of rheumatoid arthritis,″ D. R. Studelska, L Mandik -Nayak, X. Zhou, J. Pan, P. Weiser, L. M. McDowell, H. Lu, H. Liapis, P. M. Allen, F. F. Shih and L. Zhang, J. Biol. Chem. 2009, 284, 235
.L. M. McDowell, B. A. Frazier, D. R. Studelska, K. Giljum, J. Chen, J. Liu, K. Yu, D. M. Ornitz, and L. Zhang, ″ Inhibition or activation of Apert syndrome FGFR2 (S2523W) signaling by specific glycosaminoglycans,″ J. Biol. Chem. 2006, 281, 6924.
″Quantification of glycosaminoglycans by reversed-phase HPLC separation of fluorescent isoindole derivatives,″ D. R. Studelska, K. Giljum, L. M. McDowell and L. Zhang, Glycobiology, 2006, 16, 65.
″Enzymatic redesigning of biologically active heparan sulfate,″ J. Chen, F. Y. Avci, E. M. Muñoz, L. M. McDowell, M. Chen, L. C. Pedersen, L. Zhang, R. J. Linhardt and J. Liu,. J. Biol. Chem., 2005, 280, 42817
″Rotational-echo double-resonance NMR -restrained model of the ternary complex of 5-enolpyruvylshikimate-3-phosphate synthase,″ L. M. McDowell, B. Poliks, D. R. Studelska, R. D. O’Connor, D. D., Beusen and J. Schaefer, J. Biomolecular NMR, 2004, 28, 11.
″Characterization of the complex of a shikimate-based bi-substrate inhibitor and 5-enolpyruvylshikimate-3-phosphate synthase by REDOR NMR,″L. M. McDowell, L.M., Studelska, D.R., Poliks, B., O’Connor, R.D., Bartlett, P.A., and J. Schaefer, J. Biochem. 2004, 21, 6606.
″Recognition of an unnatural difluorophenyl nucleotide by uracil DNA glycosylase, ″ Y. L. Jiang, L. M. McDowell, B. Poliks, D. R. Studelska, C. Cao, G. S. Potter, J. Schaefer, F. Song, and J. T. Stivers, J. Biochem. 2004, 43, 15429.
″Human factor Xa-bound amidine inhibitor conformation by double REDOR NMR and MD simulations,″L. M. McDowell, M. A. McCarrick, D. R. Studelska, R. D. O’Connor, D. R. Light, W. J. Guilford, D. Arnaiz, J. L. Dallas, B. Poliks and J. Schaefer, J. Med. Chem. 2003, 46, 359.
″Conformation of a bound inhibitor of blood coagulant factor Xa,″ D. R. Studelska, L. M. McDowell, R. D. O’Connor, A. K. Mehta, W. J. Guilford, J. L. Dallas, D. Arnaiz, D. R. Light and Schaefer, J. Biochem. 2003, 42, 7942.
″Rotational echo double resonance detection of cross-links formed in mussel bysus under high-flow stress,″ L. M. McDowell, L. A. Burzio, J. H. Waite and J. Schaefer, J. Biol. Chem. 1999, 29, 20293.
″Conformations of trypsin-bound inhibitors of blood coagulant factor Xa by double REDOR NMR and molecular dynamics simulations,″ L. M. McDowell, M. A. McCarrick, D. R. Studelska, W. J. Guilford, D. Arnaiz, J. L. Dallas, M. Whitlow and J. Schaefer, J. Med. Chem. 1999, 42, 3910